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Articular cartilage is organized into multiple zones including superficial, middle and calcified zones with distinct cellular and extracellular components to impart lubrication, compressive strength, and rigidity for load transmission to bone, respectively. During native cartilage tissue development, changes in biochemical, mechanical, and cellular factors xvideos the formation of stratified structure of articular cartilage.

The objective of this work was to investigate the effect of combined gradients in cell density, matrix stiffness, and zone-specific growth factors on the zonal organization of articular cartilage.

Human mesenchymal stem cells hMSCs were encapsulated in acrylate-functionalized lactide-chain-extended polyethylene xvideos SPELA gels simulating cell density nude hood girls elf stiffness of the superficial, middle and calcified zones. The cell-encapsulated gels were cultivated in a medium supplemented with growth factors specific to each zone and the expression of zone-specific markers was measured with incubation time.

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Results demonstrate that a developmental approach with gradients in cell density, matrix stiffness, and zone-specific growth factors can potentially regenerate zonal structure of the articular cartilage.

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Issue 1, Previous Article Next Article. From the journal: Integrative Biology. A developmentally inspired combined mechanical and biochemical signaling approach on zonal lineage commitment of mesenchymal stem cells in articular cartilage regeneration.

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Cited by. Back to tab navigation Strap options Please wait Publication details The article was received on 12 Augaccepted on 02 Nov and first published on 05 Nov Article type: Author version available: Download author version PDF.

Download Citation: Search articles by author Tahereh Karimi. Danial Barati. Ozan Karaman.

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